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Lamotrigine
Lamotrigine
 | |
| Lamotrigine | |
| Systematic (IUPAC) name | |
| 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine | |
| Identifiers | |
| CAS number | 84057-84-1 |
| ATC code | N03AX09 |
| PubChem | 3878 |
| DrugBank | APRD00570 |
| Chemical data | |
| Formula | C9H7Cl2N5 |
| Mol. mass | 256.091 g/mol |
| SMILES | eMolecules & PubChem |
| Pharmacokinetic data | |
| Bioavailability | 98% |
| Protein binding | 55% |
| Metabolism | Hepatic |
| Half life | 24-34 hours (healthy adults) |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. | C (USA) |
| Legal status | N/A(USA); POM (UK) |
| Routes | Oral |
Lamotrigine (marketed as Lamictal (IPA: /ləˈmɪktəl/) by GlaxoSmithKline, called Lamictin in South Africa, למוג'ין (Lamogine) in Israel, and 라믹탈 in South Korea) and also Lamitor is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer. It is the first medication since lithium to be granted approval by the U.S. Food and Drug Administration (FDA) for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants (due to Lamictal being a Phenyltriazine), lamotrigine has relatively few side-effects and does not require blood monitoring in monotherapy. The exact way lamotrigine works is unknown. Some think that it is a Na+ (sodium) channel blocker, though it is interesting to note that lamotrigine shares very few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, (e.g. Oxcarbazepine), which may suggest that lamotrigine has a different mechanism of action. Lamotrigine is inactivated by hepatic glucuronidation.
Lamotrigine has a wide range of clinical uses. It has been found to be useful to treat neuropathy and also is known to be effective in treating unipolar depression, therefore patients with only these symptoms can derive an optimum benefit from lamotrigine when suffering from only these two symptoms.
However, lamotrigine has also been successful in controlling rapid cycling and mixed bipolar states in persons with more serious psychiatric disorders and who have not received what is considered to be adequate relief from lithium, carbamazepine or valproate, because it is deemed to possibly have significantly more antidepressant potency than either carbamazepine or valproate.
Lamotrigine has recently been reported to be a useful treatment for some people with post-traumatic stress disorder (PTSD) and borderline personality disorder (BPD). A recent study reported beneficial effects on individuals with schizoaffective disorder, bipolar subtype with depression.
Even more about Lamotrigine
Lamotrigine
Lamotrigine (marketed as Lamictal (IPA: /ləˈmɪktəl/) by GlaxoSmithKline, called Lamictin in South Africa, למוג'ין (Lamogine) in Israel, and 라믹탈 in South Korea) is ...
Lamotrigine - Wikipedia, the free encyclopedia
PsychEducation.org lamotrigine (Lamictal) (revised 5/2008) (Skip to the 1-line conclusion) The Good Side. Lamotrigine is another anti-seizure medication we psychiatrists have ...
